Selected Publications
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CRISPR-CasΦ from huge phages is a hypercompact genome editor
Pausch P, Al-Shayeb B, Bisom-Rapp E, et al. Science. 2020 Jul 17; 369(6501): 333–337. doi: 10.1126/science.abb1400Learn More -
CRISPR-Cas enzymes: The toolkit revolutionizing diagnostics
Verosloff MS, Shapiro SJ, Hawkins EM, et al. Biotechnol J . 2021 Sep 10;e2100304. doi: 10.1002/biot.202100304.Learn More -
CRISPR–Cas12-based detection of SARS-CoV-2
Broughton JP, Deng X, Yu G. et al.Learn More
Nat Biotechnology. 2020; doi:10.1038/s41587-020-0513-4 -
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases.
Jones SK, Hawkins JA, Johnson NV, Jung C, Hu K, Rybarski JR, Chen JS, Doudna JA, Press WH, Finkelstein IJ. https://www.biorxiv.org/content/10.1101/696393v1.Learn More -
Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics.
Ricci CG, Chen JS, Miao Y, et al. ACS Cent Sci. 2019;5(4):651–662. doi:10.1021/acscentsci.9b00020Learn More -
A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System.
Wright AV, Wang JY, Burstein D, et al. Mol Cell. 2019;73(4):727–737.e3. doi:10.1016/j.molcel.2018.12.015Learn More -
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes.
Harrington LB, Burstein D, Chen JS, et al. Science. 2018;362(6416):839–842. doi:10.1126/science.aav4294Learn More -
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.
Chen JS, Ma E, Harrington LB, et al. Science. 2018;360(6387):436–439. doi:10.1126/science.aar6245Learn More -
A thermostable Cas9 with increased lifetime in human plasma.
Harrington LB, Paez-Espino D, Staahl BT, et al. Nat Commun. 2017;8(1):1424. Published 2017 Nov 10. doi:10.1038/s41467-017-01408-4Learn More -