Selected Publications
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Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.
East-Seletsky A, O'Connell MR, Knight SC, et al. Nature. 2016;538(7624):270–273. doi:10.1038/nature19802Learn More -
CRISPR Immunological Memory Requires a Host Factor for Specificity.
Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA. Mol Cell. 2016;62(6):824–833. doi:10.1016/j.molcel.2016.04.027Learn More -
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering.
Nuñez JK, Harrington LB, Doudna JA. ACS Chem Biol. 2016;11(3):681–688. doi:10.1021/acschembio.5b01019Learn More -
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
Jiang F, Taylor DW, Chen JS, et al. Science. 2016;351(6275):867–871. doi:10.1126/science.aad8282Learn More -
Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. Nature. 2015;527(7579):535–538. doi:10.1038/nature15760Learn More -
Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes.
Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna JA. Mol Cell. 2015;60(3):398–407. doi:10.1016/j.molcel.2015.10.030Learn More -
Expanding the catalog of cas genes with metagenomes.
Zhang Q, Doak TG, Ye Y. Nucleic Acids Res. 2014;42(4):2448–2459. doi:10.1093/nar/gkt1262Learn More -