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Protein Discovery

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  • Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems.

    Chen LX, Al-Shayeb B, Méheust R, Li WJ, Doudna JA, Banfield JF. Front Microbiol. 2019;10:928. Published 2019 May 3. doi:10.3389/fmicb.2019.00928
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  • A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System.

    Wright AV, Wang JY, Burstein D, et al. Mol Cell. 2019;73(4):727–737.e3. doi:10.1016/j.molcel.2018.12.015
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  • Programmed DNA destruction by miniature CRISPR-Cas14 enzymes.

    Harrington LB, Burstein D, Chen JS, et al. Science. 2018;362(6416):839–842. doi:10.1126/science.aav4294
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  • Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

    Chen JS, Dagdas YS, Kleinstiver BP, et al. Nature. 2017;550(7676):407–410. doi:10.1038/nature24268
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  • The chemistry of Cas9 and its CRISPR colleagues.

    Chen, J., Doudna, J. Nat Rev Chem 1, 0078 (2017). https://doi.org/10.1038/s41570-017-0078
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  • A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9.

    Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. Sci Adv. 2017;3(8):eaao0027. Published 2017 Aug 4. doi:10.1126/sciadv.aao0027.
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  • Metagenomics of microbial and viral life in terrestrial geothermal environments.

    Strazzulli, A., Fusco, S., Cobucci-Ponzano, B. et al. Rev Environ Sci Biotechnol 16, 425–454 (2017). https://doi.org/10.1007/s11157-017-9435-0
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  • New CRISPR-Cas systems from uncultivated microbes.

    Burstein D, Harrington LB, Strutt SC, et al. Nature. 2017;542(7640):237–241. doi:10.1038/nature21059
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  • Rapid Thermostabilization of Bacillus thuringiensis Serovar Konkukian 97-27 Dehydroshikimate Dehydratase through a Structure-Based Enzyme Design and Whole Cell Activity Assay.

    Harrington LB, Jha RK, Kern TL, et al. ACS Synth Biol. 2017;6(1):120–129. doi:10.1021/acssynbio.6b00159
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