Selected Publications
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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.
Chen JS, Ma E, Harrington LB, et al. Science. 2018;360(6387):436–439. doi:10.1126/science.aar6245Learn More -
A thermostable Cas9 with increased lifetime in human plasma.
Harrington LB, Paez-Espino D, Staahl BT, et al. Nat Commun. 2017;8(1):1424. Published 2017 Nov 10. doi:10.1038/s41467-017-01408-4Learn More -
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
Chen JS, Dagdas YS, Kleinstiver BP, et al. Nature. 2017;550(7676):407–410. doi:10.1038/nature24268Learn More -
The chemistry of Cas9 and its CRISPR colleagues.
Chen, J., Doudna, J. Nat Rev Chem 1, 0078 (2017). https://doi.org/10.1038/s41570-017-0078Learn More -
A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, et al. Cell. 2017;170(6):1224–1233.e15. doi:10.1016/j.cell.2017.07.037Learn More -
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9.
Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. Sci Adv. 2017;3(8):eaao0027. Published 2017 Aug 4. doi:10.1126/sciadv.aao0027.Learn More -
Metagenomics of microbial and viral life in terrestrial geothermal environments.
Strazzulli, A., Fusco, S., Cobucci-Ponzano, B. et al. Rev Environ Sci Biotechnol 16, 425–454 (2017). https://doi.org/10.1007/s11157-017-9435-0Learn More -
New CRISPR-Cas systems from uncultivated microbes.
Burstein D, Harrington LB, Strutt SC, et al. Nature. 2017;542(7640):237–241. doi:10.1038/nature21059Learn More -
Rapid Thermostabilization of Bacillus thuringiensis Serovar Konkukian 97-27 Dehydroshikimate Dehydratase through a Structure-Based Enzyme Design and Whole Cell Activity Assay.
Harrington LB, Jha RK, Kern TL, et al. ACS Synth Biol. 2017;6(1):120–129. doi:10.1021/acssynbio.6b00159Learn More -