Selected Publications
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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
Chen JS, Dagdas YS, Kleinstiver BP, et al. Nature. 2017;550(7676):407–410. doi:10.1038/nature24268Learn More -
The chemistry of Cas9 and its CRISPR colleagues.
Chen, J., Doudna, J. Nat Rev Chem 1, 0078 (2017). https://doi.org/10.1038/s41570-017-0078Learn More -
A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, et al. Cell. 2017;170(6):1224–1233.e15. doi:10.1016/j.cell.2017.07.037Learn More -
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9.
Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. Sci Adv. 2017;3(8):eaao0027. Published 2017 Aug 4. doi:10.1126/sciadv.aao0027.Learn More -
New CRISPR-Cas systems from uncultivated microbes.
Burstein D, Harrington LB, Strutt SC, et al. Nature. 2017;542(7640):237–241. doi:10.1038/nature21059Learn More -
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.
East-Seletsky A, O'Connell MR, Knight SC, et al. Nature. 2016;538(7624):270–273. doi:10.1038/nature19802Learn More -
CRISPR Immunological Memory Requires a Host Factor for Specificity.
Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA. Mol Cell. 2016;62(6):824–833. doi:10.1016/j.molcel.2016.04.027Learn More -
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering.
Nuñez JK, Harrington LB, Doudna JA. ACS Chem Biol. 2016;11(3):681–688. doi:10.1021/acschembio.5b01019Learn More -
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
Jiang F, Taylor DW, Chen JS, et al. Science. 2016;351(6275):867–871. doi:10.1126/science.aad8282Learn More -