Protein Discovery
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A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System.
Wright AV, Wang JY, Burstein D, et al. Mol Cell. 2019;73(4):727–737.e3. doi:10.1016/j.molcel.2018.12.015Learn More -
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes.
Harrington LB, Burstein D, Chen JS, et al. Science. 2018;362(6416):839–842. doi:10.1126/science.aav4294Learn More -
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
Chen JS, Dagdas YS, Kleinstiver BP, et al. Nature. 2017;550(7676):407–410. doi:10.1038/nature24268Learn More -
The chemistry of Cas9 and its CRISPR colleagues.
Chen, J., Doudna, J. Nat Rev Chem 1, 0078 (2017). https://doi.org/10.1038/s41570-017-0078Learn More -
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9.
Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. Sci Adv. 2017;3(8):eaao0027. Published 2017 Aug 4. doi:10.1126/sciadv.aao0027.Learn More -
New CRISPR-Cas systems from uncultivated microbes.
Burstein D, Harrington LB, Strutt SC, et al. Nature. 2017;542(7640):237–241. doi:10.1038/nature21059Learn More -
CRISPR Immunological Memory Requires a Host Factor for Specificity.
Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA. Mol Cell. 2016;62(6):824–833. doi:10.1016/j.molcel.2016.04.027Learn More -
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
Jiang F, Taylor DW, Chen JS, et al. Science. 2016;351(6275):867–871. doi:10.1126/science.aad8282Learn More -
Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. Nature. 2015;527(7579):535–538. doi:10.1038/nature15760Learn More -