The vaccine effect on SARS-CoV-2 testing
With the roll out of the first vaccinations, there is hope that things will begin to go back to normal. So what is the outlook for SARS-CoV-2 testing in 2021? Many testing labs are asking that question.
While there is no crystal ball, many in the in vitro diagnostics industry expect that high testing demand will continue throughout at least the first half of this year. It’s likely that this high demand will continue to stress testing capacity around the world.
We have already experienced several surges in COVID-19 cases in multiple countries including the United States. We may experience new surges driven by the emergence of SARS-CoV-2 variants with greater transmissibility and possible impacts on vaccine effectiveness. Depending on multiple factors, however, projections from the Institute for Health Metrics and Evaluation indicate that COVID-19 cases and testing in the U.S. may plateau in the months ahead.
A plan to deal with peaks and valleys in COVID-19 testing
Laboratories may be thinking about how to transition from SARS-CoV-2 dominating their everyday processes to becoming a more manageable and permanent resident in the laboratory. In the long term, many predict there will still be community outbreaks. These will require high volume testing in short bursts. So how does a testing lab juggle reserving throughput for SARS-CoV-2 while meeting other testing demands?
One solution is to dedicate a single platform to SARS-CoV-2. This would free other platforms for their pre-COVID uses. Such a single, dedicated SARS-CoV-2 platform would require a consistent supply chain during swings in testing volume.
Mammoth Bioscience’s high-throughput testing solution
The Mammoth Biosciences DETECTR BOOST™ SARS-CoV-2 reagent kit is a high-throughput system that will utilize customized Agilent Bravo or Hamilton Microlab® CRISPRdetect STAR™ liquid handlers to process thousands of samples per day with less than 1 hour of hands-on time. This will be up to 5 times more tests than most other high-throughput platforms. Enabled by the speed of CRISPR, this automated platform will compress the time from sample to result. Using CRISPR detection reagents, the DETECTR BOOST™ SARS-CoV-2 reagent kit will have less supply chain risk and comes with all reagents required for extraction through detection.
The DETECTR BOOST™ SARS-CoV-2 reagent kit meets the needs of today and tomorrow. It can provide the extra capacity needed as either your lab’s primary SARS-CoV-2 testing solution or as a backup should other platforms fail. Once testing plateaus and begins to recede, the platform can easily handle impending swings in SARS-CoV-2 testing volume in a single batch per day. This will reduce the need to juggle other assays on other platforms. Once SARS-CoV-2 testing falls to less than 1,000 test per day, the DETECTR BOOST™ SARS-CoV-2 Reagent Kit will be able to handle your entire SARS-CoV-2 testing volume in 4 hours or less.
Our DETECTR BOOST™ SARS-CoV-2 Reagent Kit is not expected to be impacted by the emerging B.1.1.7 and B.1.315 SARS-CoV-2 variants based on in silico analyses and experimental data. Mammoth will continue to monitor emerging SARS-CoV-2 variants as they arise. Beyond the current crisis, this reprogrammable platform may be able to test for other pathogens in the future.
DETECTR BOOST™ SARS-CoV-2 molecular test availability
We are preparing to submit an Emergency Use Authorization (EUA) application with the U.S. Food and Drug Administration in the near future. In the meantime, you can follow our progress on Twitter, LinkedIn and on our website at www.mammoth.bio/covid or contact us at email@example.com for more information.
This project is supported by the NIH Rapid Acceleration of Diagnostics (RADx) program and has been funded in whole or in part with Federal funds from the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N92020C00011.